Trifluoromethyl group in the synthesis of heterocyclic compounds: New and efficient synthesis of 3-aryl-4-aminocinnolines

Article abstract of DOI:10.1016/0040-4039(95)00005-W

A novel base-induced transformation of hydrozones 3a-f derived from trifluoromethylaryl ketones and arylhydrazines was found to produce 3-aryl-4-aminocinnolines 4a-g in 52-75% yield. The initial step of the reaction is believed to involve abstraction of H