Retinoids. 6. Preparation of alkyl- and trimethylsilyl-substituted retinoids via conjugate addition of cuprates to acetylenic esters

Article abstract of DOI:10.1021/jo00379a016

Five retinoids bearing the ethyl, tert-butyl, and trimethylsilyl groups in the 9-position of retinal and the ethyl and tert-butyl groups in the 13-position have been synthesized. The key step of the syntheses involves the conjugate addition of lithium die