Asymmetric synthesis of an isoxazolidine nucleoside analog of thymine polyoxin C

DOI: 10.1016/S0040-4039(98)01323-9

Source and publish data:

Tetrahedron Letters p. 6411 - 6414 (1998)

Update date:2022-07-29

Topics:

Authors:

Merino, Pedro

Franco, Santiago

Merchan, Francisco L.

Tejero, Tomas

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Article abstract of DOI:10.1016/S0040-4039(98)01323-9

The first synthesis of an isoxazolidine amino acid nucleoside analog is reported. The key step of the synthesis is the stereoselective nucleophilic addition of a silyl ketene acetal to the N-benzyl nitrone derived from N,O- isopropylidene-L-serinal. The o

Full text of DOI:10.1016/S0040-4039(98)01323-9

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