Journal of Organic Chemistry p. 996 - 1001 (1987)
Update date:2022-09-26
Topics:
Sugawara, Koko
Tsunakawa, Mitsuaki
Konishi, Masataka
Kawaguchi, Hiroshi
Krishnan, Bala
et al.
The structures of new antitumor antibiotics elsamicins A (1a) and B (1b), produced by an unidentified actinomycete strain J907-21, have been established by a combination of chemical degradation, spectral analysis, and X-ray diffraction.They are structurally similar to chartreusin containing chartarin as an aglycon, but differ to each other in sugar moieties.Elsamicin A possesses two novel sugars, 2-amino-2,6-dideoxy-3-O-methyl-D-galactose and 6-deoxy-3-C-methyl-D-galactose.The presence of the amino sugar makes elsamicin A remarkably water-soluble and more bioactive than chartreusin.Elsamicin B differs from elsamicin A in that it lacks the amino sugar moiety.
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