Biological and Pharmaceutical Bulletin p. 1076 - 1081 (1997)
Update date:2022-07-29
Topics:
Ohta, Akihiro
Takahashi, Hiromitsu
Miyata, Naoomi
Hirono, Hiroyuki
Nishio, Toyotaka
Uchino, Etsuo
Yamada, Kenji
Aoyagi, Yutaka
Suwabe, Yasushi
Fujitake, Masayuki
Suzuki, Takahiro
Okamoto, Kazuo
This report describes the anti-platelet aggregation activity of 48 pyrazines. Among alkyl- and arylpyrazines tested, 2,3-diphenylpyrazines showed the strongest anti-platelet aggregation activity. Then, various substituents were introduced into the phenyl groups, and the 2,3-bis(p- methoxyphenyl)pyrazine derivatives were consequently found to possess considerably strong inhibitory activity.
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