Total Synthesis of Amphoteronolide B and Amphotericin B. 1. Strategy and Stereocontrolled Construction of Key Building Blocks

DOI: 10.1021/ja00222a028

Source and publish data:

Journal of the American Chemical Society p. 4672 - 4685 (1988)

Update date:2022-08-05

Topics:

Authors:

Nicolaou, K. C.

Daines, R. A.

Uenishi, J.

Li, W. S.

Papahatjis, D. P.

Chakraborty, T. K.

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Article abstract of DOI:10.1021/ja00222a028

The retrosynthetic analysis and strategy for the total synthesis of amphotericin B (1) and amphoteronolide B (2) is discussed.Focusing on subtle and repeated structural units, a retrosynthetic scheme was constructed that led to the recognition of readily

Full text of DOI:10.1021/ja00222a028

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