Catalytic asymmetric formation of secondary allylic amines by aza-Claisen rearrangement of trifluoroacetimidates

Article abstract of DOI:10.1055/s-2008-1077792

A catalytic asymmetric synthesis of unprotected secondary allylic amines based on the aza-Claisen rearrangement of N-ar-yl- and N-alkyl-substituted trifluoroacetimidates has been developed, which provides the targeted products with excellent enantioselectivity.