Exploring nitrone chemistry: Towards the enantiodivergent synthesis of 6-substituted 4-hydroxypipecolic acid derivatives

Article abstract of DOI:10.1002/ejoc.200800348

A methodology for the stereoselective preparation of all-cis 6-substituted 4-hydroxypipecolic acid derivatives using nitrone chemistry, involving both nucleophilic additions and cycloadditions, is presented. The N-benzyl nitrone derived from 1,2-di-O-isop