Bioorganic and Medicinal Chemistry Letters p. 2269 - 2272 (2001)
Update date:2022-07-30
Topics:
Sundar
Jacob
Bhat, Sujata V
Valecha, Neena
Biswas, Sukla
Twelve t-butylperoxyamines (6-17) were synthesized as targeted antimalarials and evaluated for antimalarial activity in vivo against Plasmodium berghei in mice and in vitro against both chloroquine sensitive and chloroquine resistant strains of Plasmodium falciparum. Compound 8 was found to have highest potency with activity at 80 and 160 mg/kg dose in vivo and compound 11 exhibited highest efficacy in vitro.
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