STEREOCONTROLLED FUNCTIONALIZATION OF CYCLOHEPTADIENE; AN APPROACH TO TYLOSIN AND CARBOMYCIN B FROM A COMMON INTERMEDIATE

Article abstract of DOI:10.1016/S0040-4039(00)84728-0

Bromolactonization of the cycloheptadienylacetic acid 1 proceeds with good regio- and stereocontrol and provides 4 which serves as a common intermediate for right hand sections of two macrolide antibiotics, tylosin and carbomycin B.