Renin Inhibitors. Design of Angiotensinogen Transition-State Analogues Containing Novel (2R,3R,4R,5S)-5-Amino-3,4-dihydroxy-2-isopropyl-7-methyloctanoic Acid

DOI: 10.1021/jm00389a004

Source and publish data:

Journal of Medicinal Chemistry p. 976 - 982 (1987)

Update date:2022-08-03

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Authors:

Thaisrivongs, Suvit

Pals, Donald T.

Kroll, Lisa T.

Turner, Steve R.

Han, Fu-Son

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Article abstract of DOI:10.1021/jm00389a004

A highly stereoselective synthesis of 2(R)-<5(R)-<1(S)-<(tert-butyloxycarbonyl)amino>-3-methylbutyl>-2,2-dimethyl-4(R)-dioxolanyl>-3-methylbutanoic acid (11) is described.This is a suitably protected carboxylic acid useful as an intermediate for the prepa

Full text of DOI:10.1021/jm00389a004

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