PROTECTION OF IMIDAZOLES AS THEIR β-TRIMETHYLSILYLETHOXYMETHYL (SEM) DERIVATIVES

Article abstract of DOI:10.1016/S0040-4039(00)84919-9

Monocyclic 4(5)-substituted imidazoles react with SEM-Cl to afford the corresponding N-SEM derivatives.These aminals readily metalate at C-2 with n-BuLi in THF at -78 deg C and react with various electrophiles.Deprotection may be achieved with either n-Bu