
Chemistry of Heterocyclic Compounds p. 495 - 499 (1986)
Update date:2022-08-04
Topics:
Romanova, N. N.
Budylin, V. A.
Grishina, G. V.
Potapov, V. M.
Demchuk, M. L.
et al.
The methylation of the lithium derivative of azethidinone-2 which has a chiral substituent at the nitrogen atom is asymmetrical and leads, with an optical yield of 35percent, to diastereomeric 3-methylated azethidinones-2.The reaction of these compounds with Na in liquid ammonia gives enantiomeric 3-methylazethidinones which confirms that an asymmetrical synthesis has taken place.
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