Novel imidazole compounds as a new series of potent, orally active inhibitors of 5-lipoxygenase

Article abstract of DOI:10.1016/S0968-0896(03)00436-X

Replacement of the dihydroquinolinone pharmacophore of Zeneca's ZD2138 by ionizable imidazolylphenyl moiety has lead to the discovery of a novel series of potent and orally active 5-lipoxygenase (5-LO) inhibitors. The synthesis and structure-activity relationship (SAR) of this series of compounds are described herein.