Journal of Medicinal Chemistry p. 1193 - 1199 (1987)
Update date:2022-07-29
Topics:
Chen, Eugene H.
Tanabe, Keiichi
Saggiomo, Andrew J.
Nodiff, Edward A.
Thirty-two 5-alkoxyprimaquines have been synthesized and evaluated as blood schizonticides (Plasmodium berghei, mouse) and tissue schizonticides (Plasmodium cynomolgi, monkey). Several of these compounds were extremely active in both screens. Such a broad spectrum of antimalarial efficacy offers the possibility of a single drug that could cure the various relapsing and nonrelapsing malarias.
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