EFFICIENT METALLOPORPHYRIN SYNTHESIS UNDER MILD CONDITIONS USING N-BENZYLPORPHYRINS

Article abstract of DOI:10.1016/S0040-4039(00)84839-X

A general method has been developed for nearly quantitative synthesis of N-benzylporphyrins by use of benzyldiphenylsulfonium tetrafluoroborate.The N-benzylporphyrins (including natural, synthetic, water soluble and non-water soluble porphyrins) insert Cu(II), Co(II), Pd(II) and Ni(II) rapidly and then readily lose the N-benzyl group to give non-N-substituted metalloporphyrins.The reactions of Cu(II), Co(II) and Pd(II) are efficient under mild conditions compatible with biological preparations.