Helvetica Chimica Acta p. 101 - 109 (1989)
Update date:2022-09-26
Topics:
Neh, Harribert
Kuehling, Andrea
Blechert, Siegfried
Substituted racemic 4,8,12-trinortaxanes were prepared stereoselectively in several steps from the dienone 10.A variant of the de Mayo reaction with bicyclononenones 4 and cyclohexen produced the desired configuration at C(8) of the taxane framework.Retro-aldol cleavage of the tetracycle 5 led to the taxane skeleton 6.Stereoselective reduction followed by treatment with base afforded 7b.Hydrolysis of the acetal group and further reduction yielded 9 in which the relative configuration corresponds to the one of the natural products.
View MoreShijiazhuang Haotian Chemical Co., Ltd.
Contact:86-311-85044374
Address:293 Donggang Road
BrightGene Bio-Medical Technology Co., Ltd.
website:https://en.bright-gene.com/
Contact:+86-512-62551801
Address:Building C25 - C31, No. 218 Xinghu Road, Suzhou Industrial Park, Suzhou, Jiangsu, China.
Hebei Kangtai Pharmaceutical Co.,Ltd
Contact:+86-0317-3512963
Address:Wugang Road,Mengcun of Cangzhou City,Hebei Province ,China
Longhui qunfeng Chemical Co., Ltd
Contact:86-731-82173407
Address:South-east Industrial Park, Longhui County, Hunan Province, China
website:http://www.mingchem.com/en/index
Contact:0519-85170101-802
Address:Fifth Floor,B of Beihua Buliding,520 Road of Science and Education City,Changwu middle road NO.801,Wujin District,Changzhou,Jiangsu province
Doi:10.1002/ejoc.201500775
(2015)Doi:10.1016/S0040-4039(00)84585-2
(1986)Doi:10.1021/jm00391a036
(1987)Doi:10.1021/acs.orglett.7b02902
(2017)Doi:10.1016/j.bmcl.2008.09.076
(2008)Doi:10.1055/s-1986-31712
(1986)
