NEW APPROACH TO THE SYNTHESIS OF DEOXYNUCLEOSIDE-PHOSPHORAMIDITE DERIVATIVES

Article abstract of DOI:10.1016/S0040-4039(00)83976-3

A new method for the synthesis of deoxyribonucleoside-phosphoramidite via an intermediate, 5'-O-dimethoxytritylthymidine-3'-O-diisopropylamino-phosphorochloridite, is reported.By using this method, several deoxyribonucleoside phosphoramidite derivatives with different protecting groups at phosphorus including P-S and P-N bond besides P-O bond were synthesized.