NEW APPROACH TO THE SYNTHESIS OF DEOXYNUCLEOSIDE-PHOSPHORAMIDITE DERIVATIVES

DOI: 10.1016/S0040-4039(00)83976-3

Source and publish data:

Tetrahedron Letters p. 199 - 202 (1986)

Update date:2022-09-26

Topics:

Authors:

Tanaka, Toshiki

Tamatsukuri, Sigeru

Ikehara, Morio

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Article abstract of DOI:10.1016/S0040-4039(00)83976-3

A new method for the synthesis of deoxyribonucleoside-phosphoramidite via an intermediate, 5'-O-dimethoxytritylthymidine-3'-O-diisopropylamino-phosphorochloridite, is reported.By using this method, several deoxyribonucleoside phosphoramidite derivatives with different protecting groups at phosphorus including P-S and P-N bond besides P-O bond were synthesized.

Full text of DOI:10.1016/S0040-4039(00)83976-3

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