Aldosterone Antagonists. 2. Synthesis and Biological Activities of 11,12-Dehydropregnane Derivatives

DOI: 10.1021/jm00392a022

Source and publish data:

Journal of Medicinal Chemistry p. 1647 - 1658 (1987)

Update date:2022-08-02

Topics:

Authors:

Kamata, Susumu

Matsui, Takeaki

Haga, Nobuhiro

Nakamura, Masuhisa

Odaguchi, Kunihiro

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00392a022

Several steroid derivatives having the Δ¹¹-pregnane skeleton with a 17-γ-spirolactone function were synthesized to evaluate their antialdosterone activity and to elucidate the relation between their binding affinity to mineralocorticoid recepto

Full text of DOI:10.1021/jm00392a022

Products guided by the article

Product name:3-<3β-acetoxy-5β,17β-dihydroxy-15β,16β-methylene-6α-(phenylseleno)androst-11-en-17α-yl>propionic acid γ-lactone

Cas No:109050-86-4

R&D Labs maybe for 109050-86-4

Dayang Chem (Hangzhou) Co.,Ltd.

website:http://www.dycnchem.com

Contact:+86-571-88938639

Address:9/F, Unit 2 Changdi Torch Building, 259# WenSan Road, Xihu District, Hangzhou City 310012, P.R.China
NANCHANG QINZHI SCI&TEC.CO.,LTD(expird)

Contact:+86-13687004106

Address:Hero South Road,Hero Zone,Nanchang,Jiangxi,China
Shanghai Balmxy Pharmaceutical Co., Ltd

Contact:0086-21-24206007

Address:Room 402, 15#, No. 909 wangyue Road, shanghai, P. R. China
Laohekou Jinghong Chemical Co.,Ltd

Contact:+86-0710-3702747

Address:163.East，Huagong Road，Laohekou
Winchem Industrial Co. Ltd.(expird)

Contact:86-574-83851061 86-574-87083208

Address:Room 905, No.3 Building,East Business Center, 456 Xingning Road, Ningbo City,China

Relevant to this article

Efficient access to 2,5-substituted tetrahydrofurans via a one-pot cyclization of di- and triepoxides

Doi:10.1016/j.tetlet.2008.09.053
(2008)
Concise synthesis and crystal structure of [12]cycloparaphenylene

Doi:10.1002/anie.201007232
(2011)
Multimetallic arrays: Symmetrical and unsymmetrical bi-, tri-, and tetrametallic organometallic complexes of ruthenium(II) and osmium(II)

Doi:10.1021/om800686f
(2009)
An expedient synthesis of 3-substituted indoles via reductive alkylation with ketones

Doi:10.1016/j.tetlet.2008.08.034
(2008)
Synthesis of novel purpurealidin analogs and evaluation of their effect on the cancer-relevant potassium channel K_V10.1

Doi:10.1371/journal.pone.0188811
(2017)
Synthesis of dinitrosyl iron complexes (DNICs) with intramolecular hydrogen bonding

Doi:10.1016/j.jorganchem.2008.08.034
(2008)

Article Doi