Aldosterone Antagonists. 2. Synthesis and Biological Activities of 11,12-Dehydropregnane Derivatives

DOI: 10.1021/jm00392a022

Source and publish data:

Journal of Medicinal Chemistry p. 1647 - 1658 (1987)

Update date:2022-08-02

Topics:

Authors:

Kamata, Susumu

Matsui, Takeaki

Haga, Nobuhiro

Nakamura, Masuhisa

Odaguchi, Kunihiro

et al. et al.

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Article abstract of DOI:10.1021/jm00392a022

Several steroid derivatives having the Δ¹¹-pregnane skeleton with a 17-γ-spirolactone function were synthesized to evaluate their antialdosterone activity and to elucidate the relation between their binding affinity to mineralocorticoid recepto

Full text of DOI:10.1021/jm00392a022

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