Fluoro ketone containing peptides as inhibitors of human renin.

DOI: 10.1021/jm00392a016

Source and publish data:

Journal of medicinal chemistry p. 1617 - 1622 (1987)

Update date:2022-08-03

Topics:

Authors:

Fearon Fearon

Spaltenstein

Hopkins Hopkins

Gelb Gelb

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00392a016

The pentapeptide BOC-Phe-Phe-difluorostatone-Leu-Phe-NH2 has been prepared and found to be a potent inhibitor of human renin. This compound contains a difluoromethylene ketone group that exists predominantly in the hydrated form in water. The difluorostat

Full text of DOI:10.1021/jm00392a016

Products guided by the article

Product name:[4(S)-({5(S)-[N-(tert-butyloxycarbonyl)amino]-6-phenyl-2(R)-(phenylmethyl)-3-trans-hexanoyl}amino)-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl]-L-leucyl-L-phenylalaninamide

Cas No:109065-00-1

R&D Labs maybe for 109065-00-1

Aqua Chem Industry Co., Ltd

Contact:+86-515-88356562

Address:No.2, West Daqing Road, Yancheng, Jiangsu, China
Dayang Chem (Hangzhou) Co.,Ltd.

website:http://www.dycnchem.com

Contact:+86-571-88938639

Address:9/F, Unit 2 Changdi Torch Building, 259# WenSan Road, Xihu District, Hangzhou City 310012, P.R.China
jiangsu senxuan pharmaceutical and chemical co.,ltd

Contact:86-523-87982810

Address:hongqiao industrial zone,taixing,jiangsu china
TLS PHARMACEUTICAL CO.,LTD

Contact:0833-5590788/5590338/5590055

Address:Victory in the town of Red Star Village,Mount Emei City,industrial concentration area storage processing logistics parkpark
Laizhou City Laiyu Chemical CO.,Ltd

Contact:+86-535-2719337/2719339

Address:Chenggang road zhuyou laizhou City Shangdong China

Relevant to this article

Mechanochemical indole synthesis by rhodium-catalysed oxidative coupling of acetanilides and alkynes under solventless conditions in a ball mill

Doi:10.1039/c7gc00499k
(2017)
Synthesis of [1,2,4]triazoloquinazolinones and imidazoquinazolinones

Doi:10.1002/jhet.5570230335
(1986)
Palladium-mediated direct synthesis of N-substituted 4-methyl- and 4-ethylisoquinolone derivatives

Doi:10.1055/s-2008-1067244
(2008)
Citrullination of linear and cyclic altered peptide ligands from myelin basic protein (MBP_87-99) epitope elicits a Th1 polarized response by T cells isolated from multiple sclerosis patients: Implications in triggering disease

Doi:10.1021/jm800891n
(2008)
2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)

Doi:10.1016/j.bmcl.2008.10.015
(2008)
Synthesis of 4-hydroxyderricin and related derivatives

Doi:10.1016/j.tetlet.2008.09.015
(2008)

Article Doi