Fluoro ketone containing peptides as inhibitors of human renin.

DOI: 10.1021/jm00392a016

Source and publish data:

Journal of medicinal chemistry p. 1617 - 1622 (1987)

Update date:2022-08-03

Topics:

Authors:

Fearon Fearon

Spaltenstein

Hopkins Hopkins

Gelb Gelb

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00392a016

The pentapeptide BOC-Phe-Phe-difluorostatone-Leu-Phe-NH2 has been prepared and found to be a potent inhibitor of human renin. This compound contains a difluoromethylene ketone group that exists predominantly in the hydrated form in water. The difluorostat

Full text of DOI:10.1021/jm00392a016

Products guided by the article

Product name:[4(S)-({5(S)-[N-(tert-butyloxycarbonyl)amino]-6-phenyl-2(R)-(phenylmethyl)-3-trans-hexanoyl}amino)-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl]-L-leucyl-L-phenylalaninamide

Cas No:109065-00-1

R&D Labs maybe for 109065-00-1

Foreschem Co., Ltd

Contact:+86-533-3112891

Address:zibo
Zhejiang Sucon Silicone Co.,Ltd

Contact:+86-575-88046692

Address:Qisheng Rd., Paojiang Industrial Zone, Shaoxing, Zhejiang, China.
Nanjing Chemipioneer Pharma&Tech Co.,Ltd

website:http://www.chemipioneer.com.cn

Contact:+86-25-52685700

Address:Room 305，A Block，Biological-Medicine Building，Business Start-up Center，Xin-ke 1st Road, High-tech development zone，Nanjing city，Jiangsu Province, China
Rudong Zhenfeng Yiyang Chemical Co., Ltd.

Contact:0513-84573047

Address:South Fengli Town, Rudong County, Jiangsu Province, China
WEIFANG RICHEM INTERNATIONAL LTD

Contact:86-536-2222176

Address:weifang,shandong

Relevant to this article

Mechanochemical indole synthesis by rhodium-catalysed oxidative coupling of acetanilides and alkynes under solventless conditions in a ball mill

Doi:10.1039/c7gc00499k
(2017)
Synthesis of [1,2,4]triazoloquinazolinones and imidazoquinazolinones

Doi:10.1002/jhet.5570230335
(1986)
Palladium-mediated direct synthesis of N-substituted 4-methyl- and 4-ethylisoquinolone derivatives

Doi:10.1055/s-2008-1067244
(2008)
Citrullination of linear and cyclic altered peptide ligands from myelin basic protein (MBP_87-99) epitope elicits a Th1 polarized response by T cells isolated from multiple sclerosis patients: Implications in triggering disease

Doi:10.1021/jm800891n
(2008)
2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)

Doi:10.1016/j.bmcl.2008.10.015
(2008)
Synthesis of 4-hydroxyderricin and related derivatives

Doi:10.1016/j.tetlet.2008.09.015
(2008)

Article Doi