Organic Letters p. 844 - 847 (2014)
Update date:2022-09-26
Topics:
Lethu, Sebastien
Matsuoka, Shigeru
Murata, Michio
An efficient synthesis involving two copper-catalyzed alkyl-alkyl coupling reactions has been designed to easily access doubly isotope-labeled fatty acids. Such NMR- and IR-active compounds were obtained in excellent overall yields and will be further used for determining the conformation of an alkyl chain of lipidic biomolecules upon interaction with proteins.
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