Bioorganic and Medicinal Chemistry Letters p. 5601 - 5604 (2008)
Update date:2022-09-26
Topics: Therapeutic applications Challenges Mechanism of Action Advantages
Blagg, Julian
Mowbray, Charles
Pryde, David C.
Salmon, Gary
Schmid, Esther
Fairman, David
Beaumont, Kevin
The optimisation of a series of amides for C5a receptor binding and functional activity, and physicochemical properties is described. The initial hit, 1 (IC50 1 μM), was discovered during high throughput screening, from which highly potent C5a receptor antagonists (e.g. 14, IC50 5 nM) were developed.
View MoreNantong Kaixin Pharma Chemical Co.,Ltd.
Contact:86-513-85250786
Address:2-1103 Huachen Mansion, 111 Gongnong Road,Nantong, Jiangsu, China
Shanghai AoBo Bio-Pharmaceutical Technology Co., Ltd.
Contact:+86-21-51320130-801, 816
Address:Room 601, No. 1011, Halei Road, Zhangjiang High-Tech Park, Pudong, Shanghai
Shanghai Egoal Chemical Co.,Ltd
Contact:+86-21-50333091
Address:Yangming Garden Square 3,YangGao North Road 1188, Pudong New District, Shanghai
NINGBO YINLIANG FOREIGN TRADE CO., LTD.
Contact:+86-574-87834016 / 87898057
Address:23F NO.666JINYU ROAD,YINGZHOU DISTRICT,NINGBO.CHINA
Contact:0086-27-83607103/83642615
Address:No.498, Jianshe Ave, Wuhan, China
Doi:10.1021/ja01186a057
(1948)Doi:10.1016/S0040-4020(01)85909-3
(1988)Doi:10.1016/j.bioorg.2021.105153
(2021)Doi:10.1081/SCC-200050959
(2005)Doi:10.1021/jo01060a048
(1961)Doi:10.1016/j.ejmech.2006.06.011
(2006)
