BF3-OEt2/Et3SiH-mediated rearrangement of 4-aryl-5,5-diphenylazapan-4-ols

Article abstract of DOI:10.1002/jccs.200700232

Synthesis of 2-(2-arylethyl)-3,3-diphenylpyrrolidines has been established starting from different 4-aryl-5,5-diphenylazepan-4-ols via boron trifluoride etherate/triethylsilane-mediated rearrangement.

Full text of DOI:10.1002/jccs.200700232

Journal of the Chinese Chemical Society, 2007, 54, 1645-1649
1645
Note
BF3-OEt2/Et3SiH-mediated Rearrangement of
4-Aryl-5,5-diphenylazapan-4-ols
Meng-Yang Changa,* (
), Yung-Hua Kunga (
) and Shui-Tein Chenb (
)
aDepartment of Applied Chemistry, National University of Kaohsiung, Kaohsiung 811, Taiwan, R.O.C.
bInstitute of Biological Chemistry, Academia Sinica, Nankang, Taipei 115, Taiwan, R.O.C.
Synthesis of 2-(2-arylethyl)-3,3-diphenylpyrrolidines has been established starting from different
4-aryl-5,5-diphenylazepan-4-ols via boron trifluoride etherate/triethylsilane-mediated rearrangement.
Keywords: Rearrangement; Boron trifluoride etherate; Triethylsilane;
2-(2-Arylethyl)-3,3-diphenylpyrrolidine; 3,3-Diphenylazepan-4-one.
INTRODUCTION
reagents and the combination of BF3-OEt2 and Et3SiH in
good yields.
Recently, we explored some interesting rearrange-
ment reactions toward different structural frameworks such
as the regioselective Baeyer-Villiger reaction, ring-con-
tractions and isomerization reactions via a convenient com-
bination of m-chloroperoxybenzoic acid (MCPBA)/boron
trifluoride etherate (BF3-OEt2) as shown in Fig. 1.1-2 Con-
tinuing our investigation on the rearrangement,1d treatment
of seven-membered 5,5-diphenylazepan-4-one3 with Grig-
nard reagent and followed by treatment of the resultant
compound with this combination of boron trifluoride ether-
ate (BF3-OEt2) and triethylsilane (Et3SiH) were further in-
vestigated. Herein, an easy and straightforward methodol-
ogy for synthesizing the framework of five-membered 2-
(2-arylethyl)-3,3-diphenyl-1-tosyl-pyrrolidine is described
from the seven-membered 5,5-diphenylazepan-4-one via
the regiospecific ring-contraction with different Grignard
RESULTS AND DISCUSSION
For investigating the BF3-OEt2/Et3SiH-mediated re-
arrangement, 4,4-diphenylmethylenepiperidine 1 was eas-
ily synthesized from 4-benzoyl-1-tosylpiperidine via Grig-
nard addition with phenylmagnesium bromide in tetrahy-
drofuran and followed by dehydration with BF3-OEt2 in di-
chloromethane according to our preliminary experience.1d
As shown in Scheme I, the sole seven-membered 5,5-di-
phenylazepan-4-one 2 was obtained in 30 mini-mole scale
from the six-membered 4,4-diphenylmethylenepiperidine
1 via pinacol-type ring-expansion rearrangement.
Next, treatment of 5,5-diphenylazepan-4-one 2 with
phenylmagnesium bromide and followed by dehydration
Fig. 1. Some interesting rearrangement reactions toward different structural frameworks.

1646 J. Chin. Chem. Soc., Vol. 54, No. 6, 2007
Chang et al.
Scheme I Synthesis of 2-(2-arylethyl)-3,3-diphenyl-1-tosyl-pyrrolidines 3a~3f
with BF3-OEt2 in Et3SiH did not afford the predicted prod-
uct of 4-phenyl-5,5-diphenyl-3-azepane with a seven-mem-
bered skeleton. Interestingly, the five-membered skeleton
of 2-(2-phenylethyl)-3,3-diphenylpyrrolidine 3a was gen-
erated in 85% yield during the rearrangement procedure.
In order to demonstrate the regioselective ring-contrac-
tion reaction, compound 2 was further treated with five
other arylmagnesium bromide reagents (b, 2-CH3C6H4; c,
2-CH3OC6H4; d, 3-CH3OC6H4; e, 4-CH3OC6H4; f, 2,6-
(CH3)2C6H3) in tetrahydrofuran at -78 °C for 5 h and fol-
lowed by BF3-OEt2/Et3SiH-mediated rearrangement at 0
°C for 2 h to afford the sole 2-(2-arylethyl)-3,3-diphenyl-
pyrrolidines 3b~3f in 65~89% overall yields in two-steps.
During the specific regioselective ring-contraction pro-
cess, the other possible frameworks were not observed.
How is the ring-contraction of compound 3 initiated
by the BF3-OEt2/Et3SiH system? The explanation would be
that BF3-OEt2/Et3SiH-mediated dehydration of tertiary al-
cohol is controlled by involvement of the nitrogen lone pair
on an azepane skeleton (see Scheme I). The initial event
may be considered to be the formation of the intermediate
I. Next, bicyclic intermediate II is formed by an intramo-
lecular ring-closure of intermediate I and followed by the
Ar group 1,3-shift of intermediate II. Finally, compounds
3a~3f were yielded by a hydride reduction of intermediate
III. The unique structural skeleton of 3,3-diphenylpyr-
rolidine 3a with 2-phenylethyl side chain was determined
by single-crystal X-ray analysis as shown in diagram 1.4 It
is worth noting that the geminal diphenyl groups at the
pyrrolidine ring could be used as useful building blocks in
Diagram 1 X-ray crystallography of compound 3a

BF3-OEt2/Et3SiH-mediated Rearrangement
J. Chin. Chem. Soc., Vol. 54, No. 6, 2007 1647
search of various compounds with different applications.5
In summary, we developed an easy and straightfor-
ward methodology for synthesizing the framework of five-
membered 2-(2-arylethyl)-3,3-diphenyl-1-tosyl-pyrroli-
dine 3 via regiospecific ring-contraction of 3,3-diphen-
yl-1-tosyl-azepan-4-one 2 with the combination of differ-
ent Grignard reagents and the combination of BF3-OEt2
and Et3SiH in good yields. Further application of this meth-
odology for the formation of new carbon-carbon bonds is
now underway.
1-Methylphenylsufonyl-3,3-diphenyl-2-(2-phenylethyl)-
pyrrolidine (3a)5
Mp = 158-159 °C; IR (CHCl3) 3447, 3025, 2917,
1731, 1598, 1495, 1338, 1161, 1094, 752, 700, 669 cm-1;
HRMS (ESI, M+ + 1) calcd for C31H32NO2S 482.2154,
found 482.2156; 1H NMR (500 MHz, CDCl3) d 7.71 (d, J =
8.5 Hz, 2H), 7.29-7.02 (m, 15H), 6.73 (d, J = 7.0 Hz, 2H),
4.75 (t, J = 5.0 Hz, 1H), 3.55 (t, J = 8.0 Hz, 1H), 3.02-2.97
(m, 1H), 2.87 (dt, J = 8.5, 12.0 Hz, 1H), 2.45 (s, 3H), 2.44-
2.38 (m, 2H), 2.20 (dt, J = 5.0, 12.0 Hz, 1H), 1.81-1.68 (m,
2H); 13C NMR (125 MHz, CDCl3) d 145.49, 143.35,
143.02, 141.90, 137.33, 129.60 (2x), 128.45 (2x), 128.32
(2x), 128.26 (2x), 128.21 (2x), 128.11 (2x), 127.12 (2x),
126.81 (2x), 126.71, 126.15, 125.60, 64.35, 58.32, 45.23,
36.62, 34.73, 32.75, 21.50; Anal. Calcd for C31H31NO2S:
C, 77.30; H, 6.49; N, 2.91. Found: C, 77.59; H, 6.88; N,
3.10. Single-crystal X-ray diagram: crystal of compound
3a was grown by slow diffusion of ethyl acetate into a solu-
tion of compound 3a in dichloromethane to yield a color-
less prism. The compound crystallizes in the monoclinic
crystal system. Space group P2(1)2(1)2(1), a = 7.1009(7)
Å, b = 8.1070(8) Å, c = 45.591(4) Å, V = 2624.5(4) Å3, Z =
4, dcalcd = 1.219 mg/m3, absorption coefficient 0.151 mm-1,
F (000) = 1024, R indices (all data) R1 = 0.1435, wR2 =
0.1328, 2q range (0.89~28.28°).
EXPERIMENTAL
General
Tetrahydrofuran (THF) was distilled prior to use. All
other reagents and solvents were obtained from commer-
cial sources and used without further purification. Reac-
tions were routinely carried out under an atmosphere of dry
nitrogen with magnetic stirring. Products in organic sol-
vents were dried with anhydrous magnesium sulfate before
concentration in vacuo. All reported melting temperatures
are uncorrected.
A representative procedure for compounds 3a~3f is
as follows
A solution of different arylmagnesium bromide re-
agents (1.0 M in THF, 1 mL, 1.0 mmol) was added to a
stirred solution of compound 2 (210 mg, 0.5 mmol) in THF
(20 mL) at -78 °C. The reaction mixture was stirred at -78
°C for 5 h. H2O (1 mL) was added to the reaction mixture
and the mixture was filtered through a short plug of Celite.
The filtrate was concentrated under reduced pressure. The
residue was extracted with H2O (10 mL) and EtOAc (3 ´ 20
mL). The combined organic layers were washed with brine,
dried, filtered and evaporated to afford crude product.
Without further purification, BF3-OEt2 (0.5 mL) was added
to a stirred solution of the crude product in Et3SiH (3 mL) at
0 °C for 2 h. Saturated NaHCO3(aq) solution (5 mL) was
added to the reaction mixture and the solvent was concen-
trated under reduced pressure. The residue was extracted
with EtOAc (3 ´ 30 mL). The combined organic layers
were washed with brine, dried, filtered and evaporated to
afford crude product. Purification on silica gel (hexane/
EtOAc = 4/1 ~ 6/1) afforded compounds 3a~3f in 65~89%
overall yields.
2-[2-(2-Methylphenyl)ethyl]-1-methylphenylsufonyl-
3,3-diphenyl-pyrrolidine (3b)
Viscous oil; IR (CHCl3) 3448, 2920, 1598, 1493,
1339, 1161, 1093, 749, 668 cm-1; HRMS (ESI, M+ + 1)
calcd for C32H34NO2S 496.2310, found 496.2309; 1H NMR
(500 MHz, CDCl3) d 7.72 (d, J = 8.5 Hz, 2H), 7.28-6.97 (m,
15H), 6.40 (d, J = 7.5 Hz, 1H), 4.80 (t, J = 4.5 Hz, 1H), 3.58
(t, J = 8.0 Hz, 1H), 2.98 (ddd, J = 5.0, 8.0, 11.5 Hz, 1H),
2.87 (dt, J = 7.5, 11.5 Hz, 1H), 2.54-2.41 (m, 2H), 2.46 (s,
3H), 2.26 (dt, J = 5.0, 12.5 Hz, 1H), 1.90 (s, 3H), 1.80-1.66
(m, 2H); 13C NMR (125 MHz, CDCl3) d 145.49, 143.51,
143.02, 140.20, 137.30, 135.91, 129.94, 129.61 (2x), 128.96,
128.38 (4x), 128.20 (2x), 127.12 (2x), 126.71 (2x), 126.68,
126.12, 125.77, 125.72, 64.67, 58.33, 45.24, 35.31, 34.77,
30.36, 21.51, 18.74.
2-[2-(2-Methoxyphenyl)ethyl]-1-methylphenylsufonyl-
3,3-diphenyl-pyrrolidine (3c)
Viscous oil; IR (CHCl3) 3446, 3024, 2953, 1599,
1493, 1338, 1244, 1161, 1106, 1031, 755, 702 cm-1; HRMS

1648 J. Chin. Chem. Soc., Vol. 54, No. 6, 2007
Chang et al.
(ESI, M+ + 1) calcd for C32H34NO3S 512.2259, found
512.2263; 1H NMR (500 MHz, CDCl3) d 7.69 (d, J = 8.0
Hz, 2H), 7.24 (d, J = 8.0 Hz, 2H), 7.19-7.07 (m, 10H),
6.79-6.71 (m, 4H), 4.85 (t, J = 4.5 Hz, 1H), 3.64 (s, 3H),
3.50 (t, J = 7.5 Hz, 1H), 3.03-2.98 (m, 1H), 2.89-2.83 (m,
1H), 2.56-2.49 (m, 1H), 2.47-2.41 (m, 1H), 2.43 (s, 3H),
2.32-2.26 (m, 1H), 1.78-1.68 (m, 2H); 13C NMR (125
MHz, CDCl3) d 157.35, 145.51, 143.60, 142.76, 137.54,
130.31, 129.89 (2x), 129.47 (2x), 128.39 (2x), 128.21 (2x),
128.16 (2x), 127.15 (2x), 126.89, 126.79 (2x), 126.38,
126.08, 120.13, 110.07, 64.79, 58.27, 54.96, 45.06, 34.61,
34.22, 27.50, 21.49.
36.83, 34.71, 31.80, 21.51.
2-[2-(2,6-Dimethylphenyl)ethyl]-1-methylphenylsufonyl-
3,3-diphenyl-pyrrolidine (3f)
Mp = 181-182 °C; HRMS (ESI, M+ + 1) calcd for
1
C33H36NO2S 510.2467, found 510.2465; H NMR (500
MHz, CDCl3) d 7.70 (d, J = 8.0 Hz, 2H), 7.27-7.24 (m, 4H),
7.20-7.14 (m, 3H), 7.05-6.98 (m, 5H), 6.93-6.86 (m, 3H),
4.89 (t, J = 5.0 Hz, 1H), 3.63-3.58 (m, 1H), 2.95-2.86 (m,
2H), 2.64 (dt, J = 4.5, 13.0 Hz, 1H), 2.57-2.50 (m, 1H),
2.48-2.40 (m, 1H), 2.44 (s, 3H), 1.97 (s, 6H), 1.84-1.75 (m,
1H), 1.67-1.59 (m, 1H); 13C NMR (125 MHz, CDCl3) d
145.13, 143.70, 142.97, 138.82, 136.73, 136.24 (2x), 129.51
(2x), 128.56 (2x), 128.21 (2x), 128.18 (2x), 127.83 (2x),
127.23 (2x), 126.62, 126.40 (2x), 126.02, 125.48, 65.46,
58.29, 45.05, 34.44, 33.89, 27.03, 21.48, 19.38 (2x); Anal.
Calcd for C33H35NO2S: C, 77.76; H, 6.92; N, 2.75. Found:
C, 77.96; H, 7.12; N, 3.03.
2-[2-(3-Methoxyphenyl)ethyl]-1-methylphenylsufonyl-
3,3-diphenyl-pyrrolidine (3d)
Mp = 138-140 °C; IR (CHCl3) 3446, 2916, 2846,
1600, 1491, 1337, 1155, 752, 700, 592 cm-1; HRMS (ESI,
M+ + 1) calcd for C32H34NO3S 512.2259, found 512.2262;
1H NMR (500 MHz, CDCl3) d 7.71 (d, J = 8.0 Hz, 2H),
7.28-7.02 (m, 13H), 6.65 (dd, J = 2.5, 8.0 Hz, 1H), 6.34 (d,
J = 7.5 Hz, 1H), 6.24 (s, 1H), 4.74 (t, J = 4.5 Hz, 1H), 3.72
(s, 3H), 3.55 (t, J = 8.0 Hz, 1H), 3.02-2.97 (m, 1H), 2.86
(dt, J = 8.0, 12.0 Hz, 1H), 2.45 (s, 3H), 2.43-2.37 (m, 2H),
2.18 (dt, J = 5.0, 12.0 Hz, 1H), 1.80-1.67 (m, 2H); 13C
NMR (125 MHz, CDCl3) d 159.40, 145.48, 143.51, 143.35,
143.05, 137.32, 129.61 (2x), 129.05, 128.48 (2x), 128.25
(2x), 128.21 (2x), 127.10 (2x), 126.81 (2x), 126.70, 126.16,
120.70, 113.77, 111.23, 64.26, 58.33, 55.08, 45.24, 36.50,
34.73, 32.82, 21.49; Anal. Calcd for C32H33NO3S: C,
75.11; H, 6.50; N, 2.74. Found: C, 75.32; H, 6.26; N, 2.86.
ACKNOWLEDGEMENT
The authors would like to thank the National Science
Council (NSC-95-2113-M-390-003-MY2) of the Republic
of China for financial support.
Received April 30, 2007.
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