Chemoenzymatic convergent synthesis of 2'-o,4'-c-methyleneribonucleosides

DOI: 10.1021/jo5008338

Source and publish data:

Journal of Organic Chemistry p. 6336 - 6341 (2014)

Update date:2022-07-30

Topics:

Authors:

Sharma, Vivek K.

Kumar, Manish

Olsen, Carl E.

Prasad, Ashok K.

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Article abstract of DOI:10.1021/jo5008338

Novozyme-435-catalyzed efficient regioselective acetylation of one of the two diastereotopic hydroxymethyl functions in 3-O-benzyl-4-C-hydroxymethyl-1,2- O-isopropylidene-α-d-ribofuranose has been achieved. The enzymatic methodology has been successfully

Full text of DOI:10.1021/jo5008338

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