Highly diastereoselective reduction and alkylation of (1R,2S)-trans-2-phenylcyclohexanol phenylglyoxylate and pyruvate using hindered hydrides and alkyl aluminates

DOI: 10.1016/S0040-4039(99)01415-X

Source and publish data:

Tetrahedron Letters p. 6919 - 6922 (1999)

Update date:2022-07-29

Topics:

Authors:

Boireau, Gerard

Deberly, Alain

Loupy, Andre

Monteux, Daphne

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Article abstract of DOI:10.1016/S0040-4039(99)01415-X

(1R,2S)-trans-2-Phenylcyclohexanol phenylglyoxylate and pyruvate are reduced with modest to excellent diastereoselectivities (30-99%) by reaction with bulky lithium trialkoxyaluminohydrides and alkylated with excellent diastereoselectivities (88-100%) by

Full text of DOI:10.1016/S0040-4039(99)01415-X

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