Tetrahedron p. 12867 - 12874 (1997)
Update date:2022-08-03
Topics:
Smrcina, Martin
Majer, Pavel
Majerova, Eva
Guerassina, Tatiana A.
Eissenstat, Michael A.
A facile stereoselective method for the synthesis of γ-substituted, γ-amino acids from α-amino acids was developed. The key step of the procedure is complete reduction of the keto functionality of α-amino acyl Meldrum's acid by sodium acetoxyborohydride. The resulting amino alkyl Meldrum's acid undergoes thermal decarboxylative ring closure to a 5-substituted pyrrolidinone which yields the corresponding γ-amino acid after basic hydrolysis. The overall yield of the procedure ranges from 40 to 65%.
View MoreJiangsu Zenji Pharmaceuticals LTD
Contact:+86-025-83172562; +1-224-888-1133(USA)
Address:No.5 Xinmofan Road
Contact:0571-
Address:zhejing
Suzhou Ryan Pharmachem Technology Co.,Ltd
Contact:+86-0512-68780025
Address:B-301,No.2 Taishan Road,Suzhou New District,Jiangsu,P.R. China
Contact:+86-913-2223392
Address:No. 32, Xinanjing Road, Weinan City, Shaanxi Province, 714000, China
SuZhou Hua-Emy Chemical Import and Export Co., LTD.
Contact:+86-512-88804994; +86-512-88804550;
Address:710, Building B, International Trade Center, 12 Huanghelu, Changshu, Jiangsu,China
Doi:10.1016/j.tet.2008.08.096
(2008)Doi:10.1016/0022-328X(86)80214-5
(1986)Doi:10.1016/S0040-4039(00)84956-4
(1986)Doi:10.1039/b813371a
(2008)Doi:10.1021/jo301282n
(2012)Doi:10.1039/jr9610003052
(1961)