Journal of Organic Chemistry p. 7046 - 7051 (2012)
Update date:2022-08-03
Topics: Cyclization Palladium catalyst Oxidative Addition Reductive Elimination Insertion Water Amine (R-NH2)
Hikawa, Hidemasa
Ino, Yukari
Suzuki, Hideharu
Yokoyama, Yuusaku
A novel method for the synthesis of 4-phenylquinazolinones via a palladium-catalyzed domino reaction of o-aminobenzamides with benzyl alcohols is developed. This protocol involves N-benzylation, benzylic C-H amidation, and dehydrogenation in water, which may play an important role in the smooth generation of the (η3-benzyl)palladium species by activation of the hydroxyl group of the benzyl alcohol.
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