Bioorganic and Medicinal Chemistry Letters p. 6293 - 6297 (2008)
Update date:2022-08-05
Topics:
Stiff, Cory
Graber, David R.
Thorarensen, Atli
Wakefield, Brian D.
Marotti, Keith R.
Melchior, Earline P.
Sweeney, Michael T.
Han, Fusen
Rohrer, Douglas C.
Zurenko, Gary E.
Romero, Donna L.
The discovery and initial optimization of a novel anthranilic acid derived class of antibacterial agents has been described in a recent series of papers. This paper describes the discovery of 1-acylindazol-3-ols as a novel bioisostere of an anthranilic acid. The synthesis and structure-activity relationships of the indazol bioisosteres are described herein.
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