Synthesis and cytotoxicity of 8-cyano-3-substitutedalkyl-5-methyl-4- methylene-7-methoxy-3,4-dihydropyrido[4,3-d]pyrimidines

DOI: 10.1016/j.bmcl.2011.07.067

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 5975 - 5977 (2011)

Update date:2022-08-02

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Authors:

Mo, Wen-Yan

Liang, Yong-Ju

Gu, Yu-Cheng

Fu, Li-Wu

He, Hong-Wu

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Article abstract of DOI:10.1016/j.bmcl.2011.07.067

Synthesis and cytotoxicity of 11 4-methylene pyrido[4,3-d]pyrimidines 5a-k were described. Cytotoxicity assay results showed that some compounds had much stronger antitumor activity than Fluorouracil against KB cell lines. The most active compound 5i exhi

Full text of DOI:10.1016/j.bmcl.2011.07.067

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