Pentamidine congeners. 2. 2-Butene-bridged aromatic diamidines and diimidazolines as potential anti-Pneumocystis carinii pneumonia agents

DOI: 10.1021/jm00052a014

Source and publish data:

Journal of Medicinal Chemistry p. 4554 - 4557 (1994)

Update date:2022-08-02

Topics:

Authors:

Donkor Donkor

Tidwell Tidwell

Jones Jones

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00052a014

We have synthesized cis and trans geometric isomers 1-8 as semirigid congeners of pentamidine. Compounds 1-4 were more potent than pentamidine in treating Pneumocystis carinii pneumonia in immunosuppressed rats. These compounds also demonstrated no clinic

Full text of DOI:10.1021/jm00052a014

Products guided by the article

Product name:(E)-4,4'-(but-2-ene-1,4-diylbis(oxy))dibenzimidamide

Cas No:109820-98-6

R&D Labs maybe for 109820-98-6

zhangjiagang bonded areas banggao co;ltd

website:http://www.shunchangchem.com

Contact:0086-13921972933

Address:Dongsha Chemical Zone.Zhangjiagang, Jiangsu Province
Jitat Company Ltd

Contact:852-27701081

Address:Room 2509, New Tech Plaza, 34 Tai Yau St., San Po Kong, HK
SHANDONG AONA CHEMICAL CO.,LTD.

Contact:86-532-85762926

Address:LIUYUAN TOWN, ZAOZHUANG CITY, SHANGDONG PROVINCE.
YanCheng LongShen Chemical Co.,Ltd.

Contact:+86-515-86668866

Address:No.13,Weiyi Road,Funing Aoyang Industrial Park
Suzhou Ryan Pharmachem Technology Co.,Ltd

Contact:+86-0512-68780025

Address:B-301,No.2 Taishan Road,Suzhou New District,Jiangsu,P.R. China

Relevant to this article

En route to polyene macrolide total synthesis; the key chiral segments of roflamycoin

Doi:10.1016/S0040-4039(00)85073-X
(1986)
Hantupeptin A, a cytotoxic cyclic depsipeptide from a Singapore collection of Lyngbya majuscula

Doi:10.1021/np800448t
(2009)
Unprecedented single-pot protocol for the synthesis of N1, C6-linked bicyclic 3,4-dihydropyrimidinones via lithiation of Biginelli compounds

Doi:10.1016/j.tet.2008.10.001
(2008)
A STEREOSELECTIVE SYNTHESIS OF THE AZASPIROUNDECANE RING SYSTEM OF (-)-HISTRIONICOTOXIN FROM (+)-GLUTAMIC ACID.

Doi:10.1016/S0040-4039(00)85162-X
(1986)
The Synthesis and Structure of Group 5 Metal Alkyl and Alkylidene Complexes containing 2,6-Dialkylphenoxide Ligands: X-Ray Crystal Structures of , , and t2-2,6)2(=CHSiMe3)(CH2SiMe3)>

Doi:10.1039/DT9870000155
(1987)
A diastereospecific, non-racemic synthesis of the C.10-C.18 segment of FK-506

Doi:10.1016/S0040-4039(00)80073-8
(1988)

Article Doi