Pentamidine congeners. 2. 2-Butene-bridged aromatic diamidines and diimidazolines as potential anti-Pneumocystis carinii pneumonia agents

DOI: 10.1021/jm00052a014

Source and publish data:

Journal of Medicinal Chemistry p. 4554 - 4557 (1994)

Update date:2022-08-02

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Authors:

Donkor Donkor

Tidwell Tidwell

Jones Jones

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Article abstract of DOI:10.1021/jm00052a014

We have synthesized cis and trans geometric isomers 1-8 as semirigid congeners of pentamidine. Compounds 1-4 were more potent than pentamidine in treating Pneumocystis carinii pneumonia in immunosuppressed rats. These compounds also demonstrated no clinic

Full text of DOI:10.1021/jm00052a014

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