Enantioselective Total Synthesis of Streptazolin. The Tandem Use of Iminium Ion-Vinylsilane Cyclizations and Intramolecular Acylations

DOI: 10.1021/ja00254a034

Source and publish data:

Journal of the American Chemical Society p. 6115 - 6118 (1987)

Update date:2022-09-26

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Authors:

Flann, Christopher J.

Overman, Larry E.

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Article abstract of DOI:10.1021/ja00254a034

The first enantioselective total syntheses of the natural antibiotic (+)-streptazolin (1) and its dihydro derivative 2 are described.Key steps are a stereoselective vinylsilane-terminated cyclization of a tartrate-derived N-acyliminium ion (17 -> 18) and

Full text of DOI:10.1021/ja00254a034

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