Antimalarial Activity of 2-(Substituted amino)-4,6-bis(trichloromethyl)-1,3,5-triazines and N-(Chlorophenyl)-N'-guanidines

Article abstract of DOI:10.1021/jm00394a002

A series of 2-<<(dialkylamino)alkyl>amino>-4,6-bis(trichloromethyl)-1,3,5-triazines (III) and N-(4-chlorophenyl)-N'-<4-<<(dialkylamino)alkyl>amino>-6-(trichloromethyl)-1,3,5-triazin-2-yl>guanidines (IV) were prepared from 2,4,6-tris(trichloromethyl)-1,3,5-triazine and 2-chloro-4,6-bis(trichloromethyl)-1,3,5-triazine.Compounds of type III showed modest antimalarial activity while XIa with the camoquin side chain was more potent.Analogues of type IV broadly exhibited modest antimalarial activity.