Journal of Medicinal Chemistry p. 1943 - 1948 (1987)
Update date:2022-08-04
Topics:
Werbel, Leslie M.
Elslager, Edward F.
Hess, Carolyn
Hutt, Marland P.
A series of 2-<<(dialkylamino)alkyl>amino>-4,6-bis(trichloromethyl)-1,3,5-triazines (III) and N-(4-chlorophenyl)-N'-<4-<<(dialkylamino)alkyl>amino>-6-(trichloromethyl)-1,3,5-triazin-2-yl>guanidines (IV) were prepared from 2,4,6-tris(trichloromethyl)-1,3,5-triazine and 2-chloro-4,6-bis(trichloromethyl)-1,3,5-triazine.Compounds of type III showed modest antimalarial activity while XIa with the camoquin side chain was more potent.Analogues of type IV broadly exhibited modest antimalarial activity.
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