Journal of Medicinal Chemistry p. 1943 - 1948 (1987)
Update date:2022-08-04
Topics:
Werbel, Leslie M.
Elslager, Edward F.
Hess, Carolyn
Hutt, Marland P.
A series of 2-<<(dialkylamino)alkyl>amino>-4,6-bis(trichloromethyl)-1,3,5-triazines (III) and N-(4-chlorophenyl)-N'-<4-<<(dialkylamino)alkyl>amino>-6-(trichloromethyl)-1,3,5-triazin-2-yl>guanidines (IV) were prepared from 2,4,6-tris(trichloromethyl)-1,3,5-triazine and 2-chloro-4,6-bis(trichloromethyl)-1,3,5-triazine.Compounds of type III showed modest antimalarial activity while XIa with the camoquin side chain was more potent.Analogues of type IV broadly exhibited modest antimalarial activity.
View MoreChengdu D-Innovation Pharmaceutical Co., Ltd
Contact:86-28-85105536
Address:1001, B6, No.88 Keyuan South Road, Chengdu Hi-Tech Zone
Shijiazhuang Sdyano Fine Chemical Co., Ltd
Contact:+86-311-89830448
Address:NO.48 Ta Nan Road,Yuhua District,Shijiazhuang,Hebei,China
Baoding City Light Industry And Textiles Imp.& Exp. Corp. Chemical Department.
Contact:86-312-3262436
Address:NO.658 CHAOYANG SOUTH STREET,BAODING CITY HEBEI CHINA
Qingdao S. H. Huanyu Imp. & Exp. Co., Ltd.
Contact:86-532-88250866
Address:Room 615, World Trade Centre Building B, Hongkong Middle Roda 6#, Qingdao, Shandong, China
Contact:86-571-86737118-8689
Address:No.69, 12 Street, HEDA, Hangzhou, Zhejiang, China
Doi:10.1002/chem.201406543
(2015)Doi:10.1002/anie.200802921
(2008)Doi:10.1002/zaac.200800107
(2008)Doi:10.1021/ja01496a062
(1960)Doi:10.1016/S0008-6215(00)90004-1
(1987)Doi:10.1021/ja01496a036
(1960)
