Synthesis and Biological Properties of α-Mono- and α-Difluoromethyl Derivatives of Tryptophan and 5-Hydroxytryptophan

DOI: 10.1021/jm00396a007

Source and publish data:

Journal of Medicinal Chemistry p. 30 - 36 (1988)

Update date:2022-08-04

Topics:

Authors:

Schirlin, D.

Gerhart, F.

Hornsperger, J. M.

Hamon, M.

Wagner, J.

Jung, M. J.

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Article abstract of DOI:10.1021/jm00396a007

The syntheses of α-mono- amd α-difluoromethyl derivatives of tryptophan and 5-hydroxytryptophan are described.In an attempt to selectively regulate serotonin synthesis, α-(mono- and difluoromethyl)tryptophan were tested in vivo as precusors (or prodrugs)

Full text of DOI:10.1021/jm00396a007

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