Journal of Medicinal Chemistry p. 30 - 36 (1988)
Update date:2022-08-04
Topics:
Schirlin, D.
Gerhart, F.
Hornsperger, J. M.
Hamon, M.
Wagner, J.
Jung, M. J.
The syntheses of α-mono- amd α-difluoromethyl derivatives of tryptophan and 5-hydroxytryptophan are described.In an attempt to selectively regulate serotonin synthesis, α-(mono- and difluoromethyl)tryptophan were tested in vivo as precusors (or prodrugs)
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