An Entry to 5-(1-Alkenyl)-3(2H)-furanones through Cycloaddition of Phosphorus-Functionalized Nitrile Oxide to Acetylene Alcohols. An Effective Synthesis of Geiparvarin

Article abstract of DOI:10.1246/cl.1987.323

Cycloaddition of α-(diethoxyphosphoryl)acetonitrile oxide to acetylene alcohols is followed by an alkylation, a reductive cleavage of the N-O bond, and an acid-catalyzed cyclization to form 5-(diethoxyphosphorylmethyl)-3(2H)-furanones in good yields.Subse