Hexafluoroisopropyl Alcohol is a Useful Cosolvent with Dimethylformamide for Tryptic Synthesis of Peptides

DOI: 10.1246/cl.1992.327

Source and publish data:

Chemistry Letters p. 327 - 330 (1992)

Update date:2022-08-04

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Authors:

Nishino, Norikazu

Xu, Ming

Mihara, Hisakazu

Fujimoto, Tsutomu

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Article abstract of DOI:10.1246/cl.1992.327

A low-water-content solvent system, 4percent H2O in hexafluoroisopropyl alcohol/dimethylformamide (1:1, v/v) was discovered for the efficient peptide synthesis catalyzed by trypsin.This mixed solvent retains potential superiority to the Klibanov's solvent

Full text of DOI:10.1246/cl.1992.327

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