Stereoselective Synthesis of (E)-5-Hydroxy-4-methyl-2-alkenoates by Palladium-Catalyzed Stereospecific Hydrogenolysis of (E)-4,5-Epoxy-4-methyl-2-alkenoates with Ammonium Formate

DOI: 10.1246/cl.1986.1775

Source and publish data:

Chemistry Letters p. 1775 - 1776 (1986)

Update date:2022-08-04

Topics: Stereoselective synthesis Palladium-Catalyzed Stereospecific Hydrogenolysis Ammonium Formate

Authors:

Shimizu, Isao

Oshima, Masato

Nisar, Mohammad

Tsuji, Jiro

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Article abstract of DOI:10.1246/cl.1986.1775

Palladium-catalyzed hydrogenolysis of (E)-4,5-epoxy-4-methyl-2-alkenoates with HCO2H-Et3N gave (E)-5-hydroxy-4-methyl-2-alkenoates in good yields with inversion of stereochemistry.

Full text of DOI:10.1246/cl.1986.1775

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Product name:Ethyl (+/-)-(E)-(4R^*,5S^*)-5-hydroxy-4-methyl-5-phenyl-2-pentenoate

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