Helvetica Chimica Acta p. 2436 - 2446 (1981)
Update date:2022-07-29
Topics:
Widmer, Erich
Zell, Reinhard
Broger, Emil Albin
Crameri, Yvo
Wagner, Hans Peter
et al.
Starting from 6-oxo-isophorone (2) a new concept for a seven-step synthesis of (3RS,3'RS)-astaxanthin (1) has been developed.As a key feature of the new approach, the oxidation state of astaxanthin (1) is adjusted already at an early stage of the synthesis.Thus, manipulation on more complex intermediates later in the synthesis is reduced to a minimum.Acetonide 10 or dimer 13 represent the key intermediates of this concept (Scheme 2).The whole sequence has been run on a kg scale with an overall yield of 52percent (s.Scheme 5).
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Doi:10.1021/ja00345a085
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(2014)
