Camphorsulfonamide derivatives: A new class of chiral catalysts for the titanium alkoxide-promoted addition of dialkylzinc to aldehydes

Article abstract of DOI:10.1016/S0957-4166(97)00272-3

The enantioselective addition of dialkylzinc to several aldehydes, using different chiral bidentate ligands (3a-j, 4a-h) [derived from (+)-10-camphorsulfonyl chloride] and titanium alkoxide as catalysts, is studied. The influence of temperature, titanium alkoxide, stoichiometry, additive, aldehyde and ligand structure is also studied.