Novel non-carboxylic acid retinoids: 1,2,4-Oxadiazol-5-one derivatives

DOI: 10.1016/j.bmcl.2008.11.040

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 489 - 492 (2009)

Update date:2022-07-30

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Authors:

Charton, Julie

Deprez-Poulain, Rebecca

Hennuyer, Nathalie

Tailleux, Anne

Staels, Bart

Deprez, Benoit

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Article abstract of DOI:10.1016/j.bmcl.2008.11.040

We have successfully obtained 1,2,4-oxadiazol-5-one bioisoteres of Am580 or Tazarotene-like retinoids. In particular compound 4 displays an EC₅₀ of 26 nM on RAR-β.

Full text of DOI:10.1016/j.bmcl.2008.11.040

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