Synthesis and analgesic activities of urea derivatives of α-amino-N-pyridyl benzene propanamide

DOI: 10.1016/0223-5234(94)90070-1

Source and publish data:

European Journal of Medicinal Chemistry p. 431 - 440 (1994)

Update date:2022-07-30

Topics:

Authors:

Sartori, E.

Camy, F.

Teulon, J. M.

Camborde, F.

Meignen, J.

at el. at el.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0223-5234(94)90070-1

New urea L-phenyl alanine derivatives of 4-aminopyridine have been synthesized and evaluated for analgesic activity with the PBQ writhing test in mice and the Randall-Selitto test in rats.Potent oral activity (ID50 < 10 mg/kg) and good tolerance were foun

Full text of DOI:10.1016/0223-5234(94)90070-1

Products guided by the article

Product name:(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-N-(3-methyl-pyridin-4-yl)-3-phenyl-propionamide

Cas No:152490-14-7

R&D Labs maybe for 152490-14-7

Xiamen Goodhealth Pharmchem Co., Ltd.

Contact:0086-592-2097683

Address:404R No.2 54# Minzu Rd., Xiamen, China
Zhengzhou Minzhong Pharmaceutical Co.,ltd

Contact:0086-371-65797115

Address:15/F,Jiangshan Bldg, NO.126 Huanghe Road,Zhengzhou, China
Shandong Hongxiang Zinc Co., Ltd

Contact:086-0311-66187879

Address:DaWang developing zone
Huayi Isotopes Co.

Contact:+ 86 512 52491118

Address:1 Fuyu Road, Haiyu TownChangshu, Jiangsu, China
Wuhan Soleado Technology Co.,Ltd.

Contact:86-2783341481 18971291927

Address:RM2405 Unit 1 Builing 1, Taiyin Tower, Changqing Road,Wuhan China

Relevant to this article

Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells

Doi:10.1038/s41418-019-0364-z
(2020)
Total syntheses of (+)-P-3A, epi-(-)-P-3A, and (-)-desacetamido P-3A

Doi:10.1021/ja00080a010
(1994)
Discovery and optimization of Lu AF58801, a novel, selective and brain penetrant positive allosteric modulator of alpha-7 nicotinic acetylcholine receptors: Attenuation of subchronic phencyclidine (PCP)-induced cognitive deficits in rats following oral administration

Doi:10.1016/j.bmcl.2013.11.022
(2014)
Two Enantioselective Syntheses of the Diol Precursor of the Biologically Most Active Isomer of an Insect Growth Regulator

Doi:10.1016/S0957-4166(00)82223-5
(1993)
STEREOSELECTIVE SYNTHESIS OF DIPYRANYL C-DISACCHARIDES

Doi:10.1016/S0040-4039(00)74040-8
(1993)
Synthesis of UDP-6-deoxy- and 6-fluoro-D-galactoses and their enzymatic glycosyl transfer to mono- and biantennary carbohydrate chains

Doi:10.1016/0040-4039(93)85060-A
(1993)

Article Doi