Synthesis and analgesic activities of urea derivatives of α-amino-N-pyridyl benzene propanamide

DOI: 10.1016/0223-5234(94)90070-1

Source and publish data:

European Journal of Medicinal Chemistry p. 431 - 440 (1994)

Update date:2022-07-30

Topics:

Authors:

Sartori, E.

Camy, F.

Teulon, J. M.

Camborde, F.

Meignen, J.

at el. at el.

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Article abstract of DOI:10.1016/0223-5234(94)90070-1

New urea L-phenyl alanine derivatives of 4-aminopyridine have been synthesized and evaluated for analgesic activity with the PBQ writhing test in mice and the Randall-Selitto test in rats.Potent oral activity (ID50 < 10 mg/kg) and good tolerance were foun

Full text of DOI:10.1016/0223-5234(94)90070-1

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