Inhibition of murine thymidylate synthase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin

DOI: 10.1021/jm00397a031

Source and publish data:

Journal of Medicinal Chemistry p. 449 - 454 (1988)

Update date:2022-08-04

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Authors:

Hynes Hynes

Patil Patil

Tomazic Tomazic

Kumar Kumar

Pathak Pathak

Tan Tan

Xianqiang

Ratnam Ratnam

Delcamp Delcamp

Freisheim

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Article abstract of DOI:10.1021/jm00397a031

A series of 5,8-dideaza analogues of folic acid, isofolic acid, aminopterin, and isoaminopterin were evaluated for inhibition of thymidylate synthase, TS, from mouse L1210 leukemia cells with 10-propargyl-5,8-dideazafolic acid, CB3717, 4a, as the referenc

Full text of DOI:10.1021/jm00397a031

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