Organic Letters p. 3290 - 3293 (2015)
Update date:2022-08-03
Topics:
Green, Robert A.
Pletcher, Derek
Leach, Stuart G.
Brown, Richard C. D.
An efficient N-heterocyclic carbene (NHC)-mediated oxidative esterification of aldehydes has been achieved in an undivided microfluidic electrolysis cell at ambient temperature. Productivities of up to 4.3 g h-1 in a single pass are demonstrated, with excellent yields and conversions for 19 examples presented. Notably, the oxidative acylation reactions were shown to proceed with a 1:1 stoichiometry of aldehyde and alcohol (for primary alcohols), with remarkably short residence times in the electrolysis cell (<13 s), and without added electrolyte. (Chemical Equation Presented).
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