Selective Amide Cleavage in Peptides Containing α,α-Disubstituted α-Amino Acids

Article abstract of DOI:10.1002/hlca.19870700213

A new synthesis of dipeptides with terminal α,α-disubstituted α-amino acids, using 2,2-disubstituted 3-amino-2H-azirines 1 as amino-acid equivalents, is demonstrated.The reaction of 1 with N-protected amino acids leads to the corresponding dipeptide amide