Chemical Communications p. 1092 - 1095 (2019)
Update date:2022-07-29
Topics:
Qian, Linghui
Pan, Sijun
Lee, Jun-Seok
Ge, Jingyan
Li, Lin
Yao, Shao Q.
c-Jun N-terminal kinases (JNKs) are involved in critical cellular functions. Herein, small-molecule JNK-targeting probes are reported based on a covalent inhibitor. Together with newly developed two-photon fluorescence Turn-ON reporters and chemoproteomic studies, we showed that some probes may be suitable for live-cell imaging and profiling of JNKs.
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