Determination of Dissociation Constants of High Affinity (pM) Human Renin Inhibitors: Application to Analogues of Ditekiren (U-71,038)

DOI: 10.1021/jm00111a028

Source and publish data:

Journal of Medicinal Chemistry p. 2107 - 2112 (1991)

Update date:2022-08-04

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Authors:

Epps, D. E.

Poorman, R. A.

Mandel, F.

Schostarez, H. J.

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Article abstract of DOI:10.1021/jm00111a028

A fluorescent human renin inhibitor, dansyl-Phe-His-LVA-Ile-Amp (3, U-80,825), was synthesized and utilized in a fluorescence energy transfer displacement assay to determine the dissociation constants (k_d's) of a series of ditekiren analogues.T

Full text of DOI:10.1021/jm00111a028

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