Synthesis of a novel cyclic sulfone dihydropyridine: An investigation of the isomerization reaction converting an exocyclic double bond isomer into a 1,4-dihydropyridine

Article abstract of DOI:10.1002/jhet.5570310216

An eight membered cyclic sulfone 1,4-dihydropyridine, RWJ 22726, 1, with remarkable cardiovascular activity was prepared by isomerization of an exocyclic double bond isomer using various reaction conditions. Under acidic and thermal isomerization conditio