Tetrahedron Letters p. 2409 - 2412 (1987)
Update date:2022-07-30
Topics: NMR spectroscopy Chiral center Stereochemistry Total synthesis Lactone Reaction Optimization Stereochemical analysis Stereocontrolled Macrocyclic lactone
Waanders, P.P.
Thijs, L.
Zwanenburg, B.
The essential features of the enantiocontrolled total synthesis of (-)-aspicilin are the strategic use of the photochemical rearrangement of α,β-epoxy diazomethyl ketones to 4-hydroxyalkenoates (Scheme 1) and the stereochemical control of the Sharpless epoxidation, α,ο functionalization of an alkynol using potassium 3-aminopropylamine (KAPA) as acetylene zipper, coupling between C7 and C8 by means of a Wittig reaction and lactonization by using 2,6-dichlorobenzoyl chloride.
View MoreZhejiang kehong chemical co., ltd
Contact:0086-575-85522000
Address:xiner center RD binhai industrial zone shaoxing zhejiang province P.R.China,312073
Zhejiang Hoshine Silicon Industry Co., Ltd.
Contact:86-573-89179966
Address:Zhapu Town, Pinghu City, Zhejiang, China
Contact:+ 86 512 52491118
Address:1 Fuyu Road, Haiyu TownChangshu, Jiangsu, China
Jinan Boss Chemical Industry Co., Ltd.【revoke the business license】
website:http://www.chemboss.com.cn
Contact:+86-531-58591595
Address:No2.Hualong Road, Jinan, China
Naturalin Bio-Resource Co., Ltd
website:http://www.naturalin.com
Contact:+86-0731-84430651
Address:B1-402, Lu-Valley Enterprise Square.No.27 Wenxuan Road. Lu-Valley Hi-Tech District.
Doi:10.1055/s-1987-28094
(1987)Doi:10.1002/anie.201610462
(2017)Doi:10.1055/s-1999-2765
(1999)Doi:10.1002/recl.19881070607
(1988)Doi:10.1016/S0957-4166(99)00151-2
(1999)Doi:10.1016/S1386-1425(01)00727-2
(2002)
