Structurally diverse 2,6-disubstituted quinoline derivatives by solid-phase synthesis

Article abstract of DOI:10.1016/0040-4039(96)00443-1

2,6-Disubstituted quinoline derivatives 12 are generated by parallel synthesis in seven steps, the last five of which proceed on a polymeric support. Variable building blocks are selected from three commercially available classes of compounds: ω-functionalized fatty acids, aryl methyl ketones, and primary amines.