Journal of Organic Chemistry p. 3006 - 3007 (1990)
Update date:2022-08-04
Topics:
Menger, F. M.
Ladika, M.
A remote enzyme-coupled amine release system has been developed in which biochemical and chemical "demasking" processes are sequentially linked via an enforced 1,3-diaxial disposition.Thus, pig liver esterase hydrolyzes an ester to an acid, and the acid promotes a fast intramolecular cleavage of an amide to an amine.The sequence has potential pharmacokinetic relevance because it allows enzyme-specific discharge of amine-based drugs following their trans-membrane journey as uncharged amides.
View MoreContact:+49-9398-993127
Address:Untertorstr. 27
Contact:+86-0592 5353131
Address:No.56 Guani Road Software Park 2,Siming District
Beijing Tianjia Chemical Science & Technology Co.,Ltd
Contact:86-0550-2392698
Address:No.388, Shiliang Road (East),
Tianjin Bright Future Technology Co., Ltd
Contact:0086-22-58016666
Address:NO.136 DongTeng Lake Street Tianjin Economic and Technology Development Area,Tainjin,China
Chemvon Biotechnology Co. Ltd.
website:http://www.chemvon.com
Contact:86-21-58550039;86-21-31268550-8004
Address:Suite B-10#, 6999 Chuansha Road, Pudong District, Shanghai 201202, China
Doi:10.1016/S0040-4039(00)96029-5
(1987)Doi:10.1246/cl.1987.1661
(1987)Doi:10.1016/j.poly.2008.11.013
(2009)Doi:10.1002/adsc.200700547
(2008)Doi:10.1021/jo982396r
(1999)Doi:10.1021/ol902133q
(2009)
