Journal of Organic Chemistry p. 3006 - 3007 (1990)
Update date:2022-08-04
Topics:
Menger, F. M.
Ladika, M.
A remote enzyme-coupled amine release system has been developed in which biochemical and chemical "demasking" processes are sequentially linked via an enforced 1,3-diaxial disposition.Thus, pig liver esterase hydrolyzes an ester to an acid, and the acid promotes a fast intramolecular cleavage of an amide to an amine.The sequence has potential pharmacokinetic relevance because it allows enzyme-specific discharge of amine-based drugs following their trans-membrane journey as uncharged amides.
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