Journal of Organic Chemistry p. 3006 - 3007 (1990)
Update date:2022-08-04
Topics:
Menger, F. M.
Ladika, M.
A remote enzyme-coupled amine release system has been developed in which biochemical and chemical "demasking" processes are sequentially linked via an enforced 1,3-diaxial disposition.Thus, pig liver esterase hydrolyzes an ester to an acid, and the acid promotes a fast intramolecular cleavage of an amide to an amine.The sequence has potential pharmacokinetic relevance because it allows enzyme-specific discharge of amine-based drugs following their trans-membrane journey as uncharged amides.
View Morewebsite:http://www.shengmaochem.com
Contact:86-27-82853423, 82819281
Address:Rm 202, A Unit Huaqiao Building No. 2, Lihuangpi Road, Wuhan, China
website:http://www.oceanchem-group.com
Contact:86-536-8596048
Address:9th floor,Building B future Plaza, No.88.Fenghuang Street,Weifang,Shandong,China
website:http://www.coreychem.com
Contact:+86-371-86658258
Address:Building 10 of Innovation Park, East District of the National University Science Park
HAINAN JINYING IMPORT AND EXPORT CO. LTD
Contact:+86-898-32875423
Address:A SECTION 19TH FL, TIMES SQUARE, NO.2 GUO MAO AVENUE HAIKOU, HAINAN, P. R. OF CHINA
Chongqing Shuangfeng Chemical Co.,Ltd
Contact:+86-23-49850156
Address:No.663,xuanhua Rd,yongchuan,chongqing,China
Doi:10.1016/S0040-4039(00)96029-5
(1987)Doi:10.1246/cl.1987.1661
(1987)Doi:10.1016/j.poly.2008.11.013
(2009)Doi:10.1002/adsc.200700547
(2008)Doi:10.1021/jo982396r
(1999)Doi:10.1021/ol902133q
(2009)
