Journal of the Chemical Society. Chemical communications p. 915 - 916 (1987)
Update date:2022-07-31
Topics:
Barluenga, Jose
Fernandez-Simon, Jose L.
Concellon, Jose M.
Yus, Miguel
Chloromethyl-lithium generated in situ, reacts at -78 deg C with ketones (5) to afford, after lithiation with lithium naphthalenide, β-oxidoalkyl-lithium compounds (1), which on reaction with electrophiles (deuterium oxide, dimethyl disulphide, carbon dioxide, cyclohexanone, and allyl bromide) yield bifunctionalized compounds (6).
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